Non-classical Monocyte Migration
Gene co-expression module in Monocytes
| Category | Migration & adhesion |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include CX3CR1 (fractalkine receptor, the defining marker of non-classical/patrolling monocytes), ITGAL (CD11a/LFA-1 alpha, leukocyte adhesion integrin), ITGA4 (CD49d/integrin alpha-4, tissue homing), LILRA1 (activating Ig-like receptor), ADGRE1 (EMR1/F4/80, tissue macrophage marker), LTB (lymphotoxin-B, immune signaling), and UTRN (utrophin, cytoskeletal). CX3CR1 and ITGAL/ITGA4 together define a non-classical monocyte migratory phenotype. ADGRE1 suggests tissue macrophage transition. Upregulated in inflammation, reduced in remission. Neighbor to M5 (also non-classical monocyte), reinforcing this identity.
Genes
ADGRE1, CX3CR1, ITGA4, ITGAL, LILRA1, LTB, SCLT1, SH2D3C, UTRN
Most correlated modules
- Non-classical Monocyte · correlation 0.81
- Myeloid Innate Receptor Signaling · correlation 0.75
- Non-classical Monocyte · correlation 0.75
- Autophagy Metabolic Stress · correlation 0.72
- Macrophage Differentiation · correlation 0.65
- GIMAP activation · correlation 0.63
- MHC II Antigen Presentation · correlation 0.62
- Type I Interferon Response · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.