IL-18 Inflammasome Response
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
IL18 is a pro-inflammatory cytokine produced by monocytes/macrophages via inflammasome activation. DEPTOR is an mTOR inhibitor that modulates inflammatory macrophage metabolism. SHMT1 (serine hydroxymethyltransferase) and ME1 (malic enzyme) are metabolic enzymes linked to one-carbon metabolism and NADPH production. NPL (N-acetylneuraminate pyruvate lyase) participates in sialic acid catabolism. EPS8 is involved in actin remodeling. The module reflects an IL-18-driven inflammatory macrophage state with associated metabolic reprogramming, decreased in remission.
Genes
CTTNBP2, DEPTOR, EPS8, IL18, LHFPL6, ME1, NPL, RNF141, SHMT1
Most correlated modules
- Efferocytosis Tissue Macrophage · correlation 0.89
- M2 Macrophage Polarization · correlation 0.82
- M2 Macrophage Polarization · correlation 0.79
- Biosynthetic Metabolic Activation · correlation 0.74
- Complement C1q Macrophage · correlation 0.73
- DNA Damage Response · correlation 0.72
- Stress-Adapted Macrophage · correlation 0.72
- Monocyte Identity · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.