mRNA splicing housekeeping
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 16 genes have a known function matching the annotation |
Why this annotation
This moderate-coherence module mixes spliceosome components (PRPF8, SF3B2, RBMX, HNRNPH3) with nuclear envelope LINC complex genes (SUN1, SYNE3), a centrosome/microtubule gene (TUBGCP2) and the kinase NEK9. It also contains scattered regulators (KLF13, USP22, TFEB). Expression is uniform, and the module neighbors other housekeeping modules. It is best interpreted as a generic mRNA splicing/nuclear housekeeping axis.
Genes
Most correlated modules
- Translation initiation housekeeping · correlation 0.89
- mTORC1 nutrient sensing · correlation 0.89
- Generic transcriptional housekeeping · correlation 0.86
- Metabolic/trafficking housekeeping · correlation 0.86
- Transcriptional coregulators · correlation 0.86
- Proteotoxic stress · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.