IRF1 Innate Activation
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
Hub gene CFLAR (c-FLIP, anti-apoptotic regulator of caspase-8/death receptor signaling), IRF1 (interferon regulatory factor 1, key innate immune transcription factor), TRIM69 (E3 ubiquitin ligase with antiviral roles), MARCKS (PKC substrate involved in inflammatory signaling), FNIP2 (FLCN-interacting protein, mTOR/AMPK pathway), ZFYVE16 (endosomal signaling), BAZ1A (chromatin remodeling). IRF1 and TRIM69 suggest interferon/innate immune transcriptional activation; CFLAR links to survival signaling during immune activation. The module is significantly upregulated in CD inflammation and reduced in remission/treatment, consistent with an IRF1-driven innate immune activation program. As a neighbor to M48 and M60, this module likely represents a complementary innate immune transcriptional arm (IRF1-driven) rather than the NF-κB arm.
Genes
BAZ1A, CFLAR, FNIP2, IRF1, MARCKS, NABP1, THAP2, TRIM69, ZFYVE16
Most correlated modules
- Inflammatory Stress Response · correlation 0.92
- Inflammasome Activation · correlation 0.88
- TNF-driven Activation · correlation 0.87
- AP-1 Stress Response · correlation 0.86
- NF-κB Signaling · correlation 0.83
- Epigenetic Inflammatory Reprogramming · correlation 0.83
- NF-κB Counter-regulation · correlation 0.82
- TNF/IL-1 Cytokine Storm · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.