Mitochondrial Import
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 3 of 13 genes have a known function matching the annotation |
Why this annotation
TYROBP (DAP12) is a key immune signaling adaptor expressed in pDCs, NK cells, and myeloid cells; COX17 is a copper chaperone for cytochrome c oxidase assembly; UQCRB is Complex III; TOMM7 is mitochondrial outer membrane import; S100A11 is a calcium-binding protein; GNG5 is a G-protein subunit; HINT1 is a signaling regulator. This module mixes mitochondrial components with immune signaling genes. TYROBP is a known pDC marker. The module likely reflects a mixed housekeeping/immune signaling program co-expressed in pDCs.
Genes
Most correlated modules
- Respiratory Chain · correlation 0.92
- Complex I Assembly · correlation 0.83
- Complex I Subunits · correlation 0.81
- Mitochondrial Ribosome · correlation 0.79
- Type I Interferon · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.