Polycomb Transcription
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes PHC3 (Polycomb repressive complex), CHD9 (chromatin helicase), KANSL1 (NSL histone acetyltransferase complex), ARID1B (SWI/SNF), TRRAP (SAGA/TIP60 HAT complex), TBL1XR1 (NCoR/SMRT corepressor complex), and UBR2 (ubiquitin E3 ligase) collectively define a transcriptional/chromatin regulatory program. TCF4 is a key pDC transcription factor but fits within the broader transcriptional regulation theme. This module neighbors M44 which also centers on chromatin remodeling, supporting a shared epigenetic regulation neighborhood. All genes show weak membership and uniform expression.
Genes
Most correlated modules
- DNA Damage Response · correlation 0.91
- Mixed Regulatory Background · correlation 0.90
- ARF-mediated Trafficking · correlation 0.88
- Actin Cytoskeleton · correlation 0.86
- pDC Identity Signaling · correlation 0.86
- Chromatin Remodeling · correlation 0.85
- Mixed Regulatory Background · correlation 0.84
- Centrosome Organization · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.