Endosomal Innate Sensing
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Antiviral |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 6 of 35 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. The gene list includes: PSMA6 (proteasome subunit), GABARAP (autophagy/LC3 family), NME2 (nucleoside diphosphate kinase), EEF1G (translation elongation), RNASEK (RNase, antiviral), ATP6V0C (vacuolar ATPase, endosomal acidification), MRPS24 (mitoribosome), TXNDC5 (thioredoxin, ER stress), BOLA2 (iron-sulfur cluster), TOMM6 (mitochondrial import), TLR9 (innate immune, CpG DNA sensing — key pDC marker), EIF4EBP3 (translation regulation), TRAPPC5 (vesicle trafficking), ABHD16A (lipid metabolism), UBE2V1 (ubiquitin conjugating enzyme), LIME1 (lymphocyte signaling), WBP1 (ER), TMEM35B, C17orf49, C18orf32. TLR9 is a canonical pDC marker and innate immune sensor. RNASEK and ATP6V0C support endosomal/antiviral sensing. GABARAP links to autophagy. However, all memberships are weak and the module is incoherent overall. The presence of TLR9 and RNASEK hints at innate/antiviral sensing but is insufficient for a confident call.
Genes
Most correlated modules
- DNA Damage Response · correlation 0.84
- Transcriptional Stress Response · correlation 0.52
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.