Transcriptional Stress Response
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 5 of 11 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. The gene list includes: EWSR1 (RNA binding, transcription), MED17 (Mediator complex, transcription), ATF4 (stress-responsive transcription factor, UPR/ISR), POLR2J3-1 (RNA polymerase II subunit), USP16 (deubiquitinase, cell cycle), MYH9 (non-muscle myosin IIA, cytoskeletal), RBM4 (RNA binding, splicing), FBXO7 (F-box protein, ubiquitin ligase), PINX1 (telomere/Pin2 interactor), KDM5B (histone demethylase), GGA1 (Golgi trafficking). ATF4 is a canonical integrated stress response/UPR transcription factor; MED17 and POLR2J3-1 suggest transcriptional regulation. However, the module is highly heterogeneous with all-weak memberships. A loose transcriptional stress theme is possible but not strongly supported.
Genes
Most correlated modules
- JAK-STAT Signaling · correlation 0.63
- DNA Damage Response · correlation 0.61
- Endosomal Innate Sensing · correlation 0.52
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.