DNA Damage Response
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 5 of 26 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. The gene list includes: ARL5A (Arf-like GTPase), ZGPAT (zinc finger), TUG1 (lncRNA), MFSD14A (transporter), MED15 (Mediator complex), EIF4A1 (translation initiation), IL10RB (IL-10 receptor beta), RBM27 (RNA binding), BCOR (transcriptional repressor), ATXN7 (SAGA complex), ABCF2 (ABC transporter), ATR (DNA damage checkpoint kinase), POLD4 (DNA polymerase delta), SRCAP (chromatin remodeling), ARHGEF18 (Rho GEF), RAD50 (DNA repair), COX16 (cytochrome c oxidase assembly), CLN3 (lysosomal), SGSM3 (Rab GAP), TMEM161B (transmembrane). Several genes (ATR, RAD50, POLD4, SRCAP) relate to DNA damage/repair, but the module is too heterogeneous and all-weak to confidently assign a single program. Likely a noisy module.
Genes
Most correlated modules
- Endosomal Innate Sensing · correlation 0.84
- Transcriptional Stress Response · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.