Autophagy & Proteostasis
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 6 of 35 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. Notable genes: RB1CC1 (RB1-inducible coiled-coil 1, autophagy initiation via ULK1 complex), STX17 (syntaxin-17, autophagosome-lysosome fusion), SMAD5 (TGF-beta/BMP signaling), YTHDC1 (m6A RNA reader, nuclear RNA processing), KMT2D (histone methyltransferase), CHD3 (chromatin remodeling), MARCHF6 (E3 ubiquitin ligase, ER-associated degradation), CASC3 (exon junction complex, NMD), DCP1A (mRNA decapping, P-bodies), DCAF16 (CRL4 ubiquitin ligase substrate receptor), HELB (DNA helicase). RB1CC1 and STX17 together strongly suggest autophagy. MARCHF6 and DCAF16 suggest ubiquitin-proteasome/ERAD. The module may loosely represent autophagy and protein quality control, though coherence is weak.
Genes
Most correlated modules
- DNA Damage Response · correlation 0.86
- Mixed Regulatory Background · correlation 0.83
- Mixed Regulatory Background · correlation 0.81
- Low-coherence Background · correlation 0.79
- Low-coherence Background · correlation 0.78
- Low-coherence Background · correlation 0.77
- Mixed Signaling Regulation · correlation 0.77
- Kinase Phosphatase Signaling · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.