Cell Cycle Regulation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 27 genes have a known function matching the annotation |
Why this annotation
Hub genes include CENPL (kinetochore component, mitosis), H2BC5 and H2BC6 (core histones, replication-coupled), CDK14 (cyclin-dependent kinase), CDKN1C (p57, cell cycle inhibitor). ARMC9 is associated with cilia/cell cycle. ZNF143 is a transcriptional regulator of cell cycle genes. The presence of histone genes and kinetochore components alongside CDKs suggests a cell cycle/proliferation-related module, though it is weakly defined. DEPDC5 (mTOR pathway) and NFIC (transcription factor) add heterogeneity.
Genes
Most correlated modules
- Epigenetic Regulation · correlation 0.79
- Chromatin Remodeling · correlation 0.76
- Mitotic Cell Cycle · correlation 0.69
- Mixed Signaling · correlation 0.63
- Cell Cycle Regulation · correlation 0.63
- Rho GEF Signaling · correlation 0.61
- IFN-Vesicular Response · correlation 0.60
- Antiviral Innate Sensing · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.