Actin Cytoskeletal Remodeling
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 4 of 20 genes have a known function matching the annotation |
Why this annotation
TAGLN2 (transgelin-2) is an actin-binding protein involved in cytoskeletal remodeling; CDKN2D (p19/INK4d) is a CDK4/6 inhibitor involved in cell cycle regulation; GRK6 phosphorylates GPCRs; NCF1 (p47-phox) is a NADPH oxidase component; RAB4A mediates fast endosomal recycling; CD37 is a tetraspanin expressed on B cells and pDCs; TSPAN3 is another tetraspanin; CADM4 is a cell adhesion molecule; GNAS encodes G-protein alpha-s; CXXC5 is a Wnt pathway regulator. The module is weakly coherent with no dominant program. TAGLN2 and cytoskeletal elements are the most represented theme. CD37 is a genuine pDC/B-cell marker but insufficient to define the module alone.
Genes
Most correlated modules
- Metabolic Housekeeping · correlation 0.92
- Fc Receptor Trafficking · correlation 0.87
- ER-Golgi Trafficking · correlation 0.87
- ER Protein Folding · correlation 0.86
- Clathrin-mediated Endocytosis · correlation 0.86
- ER Redox Homeostasis · correlation 0.85
- General Cellular Maintenance · correlation 0.84
- Lysosomal mTOR Signaling · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.