Pre-mRNA Splicing
Gene co-expression module in Plasma cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 20 genes have a known function matching the annotation |
Why this annotation
The module is dominated by heterogeneous nuclear ribonucleoproteins (HNRNPU, HNRNPA2B1, HNRNPC, HNRNPDL, HNRNPA0) and SR splicing factors (SRSF3, TRA2B, PTBP1). SFPQ, PNN, RSRC2, WBP11, and ZMAT2 are additional splicing regulators. PABPC1 is the cytoplasmic poly-A binding protein. NCL (nucleolin) is involved in rRNA transcription and ribosome biogenesis. This is a coherent pre-mRNA splicing and RNA processing module enriched in plasmablasts, consistent with the high transcriptional and splicing demands of antibody-secreting cells.
Genes
Most correlated modules
- Plasma Cell Differentiation · correlation 0.82
- Chaperone Proteostasis · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.