Plasma Cell Differentiation
Gene co-expression module in Plasma cells
| Category | IgA production |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
Moderate coherence module with uniform or mild plasmablast enrichment. Hub genes ELL2 (RNA Pol II elongation factor, essential for high-level Ig secretion in plasma cells), PRDM1 (BLIMP1, master transcription factor of plasma cell differentiation), ELF1 (ETS family TF active in B-cell/plasma cell), STK17B (DRAK2, regulates plasma cell apoptosis), DUSP4 (MAPK phosphatase, downstream of BCR/cytokine signaling), BLNK (B-cell linker protein, BCR signaling scaffold), PTPN1 (PTP1B, signaling), GRB2 (adaptor protein). ELL2 and PRDM1 together are the canonical transcriptional drivers of plasma cell identity and Ig secretion. This module represents the plasma cell differentiation transcriptional program.
Genes
Most correlated modules
- COPI Vesicle Trafficking · correlation 0.93
- Plasmablast Differentiation · correlation 0.86
- DNA Damage Response · correlation 0.85
- Innate Immune ISG · correlation 0.85
- Pre-mRNA Splicing · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.