Chaperone Proteostasis
Gene co-expression module in Plasma cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 16 genes have a known function matching the annotation |
Why this annotation
Strong coherence, uniform expression across subsets, significantly decreased with inflammation. Hub genes HSPD1 (HSP60), HSPE1 (HSP10), HSP90AB1, TCP1 (CCT1 chaperonin), AHSA1 (HSP90 co-chaperone) form a strong chaperone/proteostasis core. EIF4A3 (exon junction complex/translation), SRSF2 and SRSF7 (SR splicing factors), FUS (RNA binding protein), MRPL18 (mitochondrial ribosome) add RNA processing and translation components. VIM (vimentin) and TUBB4B (tubulin) suggest cytoskeletal involvement. PMAIP1/NOXA indicates apoptotic priming. MAT2A (methionine/SAM metabolism) supports methylation. The chaperone cluster dominates and the module is broadly expressed, consistent with a general proteostasis/chaperone stress response that is suppressed during active inflammation, possibly reflecting reduced plasma cell secretory load or stress adaptation.
Genes
Most correlated modules
- Pre-mRNA Splicing · correlation 0.80
- Heat Shock Response · correlation 0.61
- Stress-induced Quiescence · correlation 0.57
- Immediate Early TFs · correlation 0.55
- AP-1 Immediate Early · correlation 0.47
- Glucocorticoid Response · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.