DNA Replication Fork
Gene co-expression module in Plasma cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes GINS2 (GINS complex, replication fork helicase), PCNA (sliding clamp, DNA replication/repair), DHFR (dihydrofolate reductase, dTMP synthesis, S-phase), MCM4/MCM5/MCM6/MCM7 (MCM helicase complex, replication licensing and elongation), RRM1 (ribonucleotide reductase large subunit), CENPU (kinetochore), DNMT1 (maintenance methylation, replication-coupled), SLBP (histone mRNA processing, S-phase), RFC4 (replication factor C clamp loader), RAD51AP1 (homologous recombination), NASP (histone chaperone, S-phase). This module is a DNA replication fork / MCM helicase program, closely related to M40 (S-phase replication) but focused on the replisome machinery rather than nucleotide biosynthesis. Weak coherence reflects mixing of replication initiation and elongation sub-programs. No significant inflammation association distinguishes it from the other cell-cycle modules. Neighbor context: topological neighbor of M40 and M37, consistent with S-phase replication cluster.
Genes
Most correlated modules
- S-phase DNA Replication · correlation 0.97
- Replication Checkpoint S/G2 · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.