S-phase DNA Replication
Gene co-expression module in Plasma cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 15 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes TYMS, RRM2, TK1, FEN1, DUT are all enzymes of deoxyribonucleotide biosynthesis (thymidylate synthesis, ribonucleotide reduction, thymidine kinase, flap endonuclease, dUTPase), classically upregulated in S-phase. PCLAF (PCNA-associated), GMNN (geminin, replication licensing inhibitor), MCM3 (replication helicase), CHEK1 (S-phase checkpoint kinase), UBE2T (Fanconi pathway E2), ZWINT (kinetochore), CENPM, SMC1A (cohesin), MYBL2 (S/G2 transcription factor) all reinforce an S-phase DNA replication program. Strong enrichment in plasmablasts. Significant upregulation with inflammation (UC >> CD). Neighbor modules M26, M37, M41, M62, M44 are all plasmablast cell-cycle modules, confirming this is a proliferative S-phase program in cycling plasmablasts.
Genes
Most correlated modules
- DNA Replication Fork · correlation 0.97
- Spliceosome snRNP Assembly · correlation 0.95
- Replication Checkpoint S/G2 · correlation 0.94
- Mitotic Entry G2/M · correlation 0.94
- Ribosome Biogenesis · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.