Replication Checkpoint S/G2
Gene co-expression module in Plasma cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes BRCA1, CLSPN (claspin, replication checkpoint mediator), ATAD2 (chromatin remodeling in S/G2), FBXO5 (Emi1, APC/C inhibitor active in S-G2), CDC6 (replication licensing), ORC6 (origin recognition), TOPBP1 (ATR activation, replication checkpoint), CHAF1A (chromatin assembly factor, replication-coupled), ATAD5 (PCNA unloading), USP1 (deubiquitinase for PCNA/FANCD2), PSMC3IP (homologous recombination), EZH2 (PRC2, active in proliferating cells), SMC3 (cohesin), NSD2 (histone methyltransferase). This module represents the DNA damage response and replication checkpoint program active in late S/G2, distinct from the pure replication module M40 and the mitotic spindle module M41. Significant inflammation association. Neighbor context consistent with a cluster of plasmablast proliferation modules.
Genes
Most correlated modules
- S-phase DNA Replication · correlation 0.94
- DNA Replication Fork · correlation 0.93
- Mitotic Entry G2/M · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.