Mitotic Entry G2/M
Gene co-expression module in Plasma cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes HMGB2, HMGB1, HMGN2 are chromatin-associated HMG proteins that decondense chromatin during mitosis and are highly expressed in proliferating cells. STMN1 (stathmin, microtubule destabilizer active in G2/M), TUBB/TUBA1B (tubulin subunits for mitotic spindle), SMC4/SMC2 (condensin complex for chromosome condensation), TMPO (thymopoietin/LAP2, nuclear envelope disassembly in mitosis), CENPW (kinetochore), SHCBP1 (mitotic spindle), ANP32E (chromatin remodeling), VRK1 (kinase phosphorylating histones in mitosis), NUCKS1 (chromatin regulator in proliferating cells). This module captures chromosome condensation and early mitotic entry. Neighbor context: flanked by S-phase (M40, M44) and late mitosis (M41, M62) modules, placing this at G2/M transition. Moderate coherence reflects mixing of chromatin and cytoskeletal sub-programs that are both active at mitotic entry.
Genes
Most correlated modules
- Spindle Assembly Checkpoint · correlation 0.97
- S-phase DNA Replication · correlation 0.94
- Replication Checkpoint S/G2 · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.