ER Translocon Complex
Gene co-expression module in Plasma cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 18 genes have a known function matching the annotation |
Why this annotation
Strong coherence module. KDELR2 is the KDEL ER-retention receptor. SEC61G and SEC61B are subunits of the Sec61 translocon channel. OSTC, OST4, and DAD1 are oligosaccharyltransferase (OST) complex subunits - DAD1 is also known as OST2. EMC7 is part of the ER membrane protein complex facilitating membrane protein insertion. RER1 mediates ER retrieval of escaped ER proteins. DERL1 is an ERAD component (derlin-1). PPIB (cyclophilin B) is an ER luminal peptidyl-prolyl isomerase. SLC35B1 transports nucleotide sugars into the ER for glycosylation. YIF1A is involved in ER-to-Golgi trafficking. MYDGF is an ER-derived cardioprotective/growth factor. This module captures the translocon-OST supercomplex and ER retrieval machinery, complementing neighbor M16's broader ER folding program.
Genes
Most correlated modules
- ER Protein Folding · correlation 0.96
- Mitochondrial OxPhos · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.