ER Protein Folding
Gene co-expression module in Plasma cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 16 of 20 genes have a known function matching the annotation |
Why this annotation
Strong coherence module with core hub genes that are canonical ER protein processing components. MANF is an ER stress-protective luminal protein. SSR2/SSR3 are subunits of the signal sequence receptor/translocon-associated protein (TRAP) complex. RPN2 and DDOST are oligosaccharyltransferase (OST) complex subunits mediating N-glycosylation. PDIA6, P4HB (PDI), and ERP29 are protein disulfide isomerases. TMED2, TMED9, TMED10 are p24 family COPI vesicle coat proteins for ER-Golgi trafficking. LMAN2 is a lectin cargo receptor. CRELD2 is a UPR marker. AUP1 and DERL2 are ERAD components. TMBIM6 is an anti-apoptotic ER membrane protein. This module represents the core ER protein folding, N-glycosylation, and quality control machinery essential for immunoglobulin secretion in plasma cells. Neighbor M7 captures the translocon/OST supercomplex, together forming the complete ER secretory apparatus.
Genes
Most correlated modules
- ER Translocon Complex · correlation 0.96
- Translation Initiation · correlation 0.83
- Unfolded Protein Response · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.