Mitochondrial OxPhos
Gene co-expression module in Plasma cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 5 of 17 genes have a known function matching the annotation |
Why this annotation
Top hub genes are ATP5MC2 and ATP5MG (ATP synthase subunits F-type complex), followed by COX7C, COX4I1 (cytochrome c oxidase subunits), and UQCRB (ubiquinol-cytochrome c reductase, complex III). These are canonical mitochondrial oxidative phosphorylation components. Supporting genes include TMSB4X and GMFG (actin dynamics in metabolically active cells), PSMB9 (proteasome), and EIF3K (translation). The plasmablast enrichment is consistent with the high metabolic demands of antibody-secreting cells. The module is coherent and tightly centered on mitochondrial electron transport chain and ATP synthesis.
Genes
Most correlated modules
- Oxidative Phosphorylation · correlation 0.94
- Ubiquitin-like Modification · correlation 0.94
- Protein Quality Control · correlation 0.94
- Translation Initiation · correlation 0.92
- Actin Cytoskeletal · correlation 0.91
- ER Translocon Complex · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.