Actin Cytoskeletal
Gene co-expression module in Plasma cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 13 genes have a known function matching the annotation |
Why this annotation
Top hub genes are ACTG1 and ACTB (cytoplasmic actin isoforms) and TMSB10 (thymosin beta-10, actin sequestering protein), forming a clear actin cytoskeletal core. CALM2 (calmodulin, calcium signaling/actin regulation) and GMFG-neighbor PTMA (prothymosin alpha) support cytoskeletal remodeling. Peripheral genes include TXN (thioredoxin, redox), SOD1 (antioxidant), CYCS (cytochrome c), EIF5A (translation), HNRNPA1 (RNA binding), and SF3B5 (splicing), reflecting moderate coherence with mixed housekeeping/stress components. The dominant cytoskeletal signal in plasmablasts likely reflects active secretory vesicle trafficking. As a neighbor to M86 (OxPhos) and M70 (translation), this module captures the cytoskeletal infrastructure of the secretory program.
Genes
Most correlated modules
- Mitochondrial OxPhos · correlation 0.91
- Translation Initiation · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.