Translation Initiation
Gene co-expression module in Plasma cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by translation machinery: BTF3 (nascent polypeptide-associated complex beta subunit), EEF1B2 (translation elongation factor 1 beta 2), NACA (nascent polypeptide-associated complex alpha), RACK1 (receptor for activated C kinase 1, ribosome-associated), and multiple eIF3 complex subunits (EIF3E, EIF3H, EIF3F, EIF3L) plus EIF4B. EEF2 (elongation factor 2) further supports active translation. SEC11A (signal peptidase complex subunit) links to co-translational ER translocation, highly relevant for immunoglobulin-secreting plasmablasts. MYL12A/B are myosin light chains possibly involved in secretory vesicle transport. This module represents the core translational initiation and elongation program supporting high-level protein secretion in plasmablasts, consistent with its network neighborhood alongside OxPhos (M86) and cytoskeletal (M71) modules.
Genes
Most correlated modules
- Mitochondrial OxPhos · correlation 0.92
- Actin Cytoskeletal · correlation 0.88
- ER Protein Folding · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.