Translation Initiation
Gene co-expression module in Tuft cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 16 genes have a known function matching the annotation |
Why this annotation
Top hub genes EIF4E2 and EIF3B are translation initiation factors; RBM8A is part of the exon junction complex; PCBP2 and YBX3 are RNA-binding proteins regulating mRNA stability and translation. CLUH clusters mRNAs encoding mitochondrial proteins. MLXIP (ChREBP-beta) is a glucose-responsive transcription factor. HADHB encodes mitochondrial trifunctional protein beta subunit (fatty acid oxidation). SELENOS is an ER-resident selenoprotein. The module is dominated by RNA processing and translational control machinery active in pre-tuft progenitors.
Genes
Most correlated modules
- Mitochondrial Biogenesis · correlation 0.95
- Tuft Cytoskeletal Remodeling · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.