Mitochondrial Biogenesis
Gene co-expression module in Tuft cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
UQCRC2 (Complex III core subunit), NDUFV1 (Complex I subunit), ETFA (electron transfer flavoprotein for fatty acid/amino acid oxidation), CS (citrate synthase, TCA cycle entry), MRPL16 (mitoribosome large subunit), TRAP1 (mitochondrial HSP90 paralog) form a tight mitochondrial OxPhos/biogenesis core. MCM3 (MCM helicase, DNA replication), NASP (histone chaperone), IPO7 (importin-7) suggest concurrent cell cycle activity. EPHB3 marks crypt progenitor positioning. The module reflects mitochondrial biogenesis and OxPhos upregulation during pre-tuft specification.
Genes
Most correlated modules
- Translation Initiation · correlation 0.95
- MYC-driven Biosynthesis · correlation 0.94
- Pre-tuft Differentiation · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.