Proteasome Assembly
Gene co-expression module in Tuft cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes FKBP1A (FK506-binding protein/chaperone for protein folding) and POMP (proteasome maturation protein, essential for 20S proteasome assembly) anchor this module in protein folding and proteasome biogenesis. RSL24D1 (60S ribosome biogenesis factor), NAP1L1 (nucleosome assembly protein), BZW1 (translation initiation), and SYNCRIP (hnRNP RNA-binding protein) support active RNA processing and translation. TUBB (beta-tubulin) and SH3BGRL3 (thioredoxin-like redox) add cytoskeletal and redox components. CTSZ (lysosomal cathepsin) and VDAC2 (mitochondrial outer membrane) contribute to proteolytic and metabolic housekeeping. All genes are enriched in pre_tuft progenitors. In the context of neighbors M35 (proliferation) and M50 (vesicle trafficking), this module represents the proteasome assembly and protein folding arm of the pre_tuft progenitor biosynthetic state.
Genes
Most correlated modules
- Progenitor Cell Proliferation · correlation 0.94
- ER Vesicle Trafficking · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.