Progenitor Cell Proliferation
Gene co-expression module in Tuft cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes RAN (nuclear transport GTPase essential for mitosis), CDK4 (G1/S cyclin-dependent kinase), and FBL (fibrillarin, rRNA methylation/ribosome biogenesis) anchor this module in cell proliferation. EIF3F (translation initiation factor), FARSB (aminoacyl-tRNA synthetase), and APRT (purine nucleotide synthesis) support active biosynthesis in dividing cells. All genes are strongly enriched in pre_tuft progenitor cells, consistent with a proliferating precursor state. GLRX5 supports mitochondrial function needed for rapid division. The module is tightly co-regulated (core coherence) and neighbors M50/M57 share the pre_tuft progenitor context, collectively representing the biosynthetic programs of tuft cell precursors.
Genes
Most correlated modules
- Mitotic Spindle Assembly · correlation 0.98
- Cobalamin Uptake Program · correlation 0.98
- Ribosome Biogenesis · correlation 0.98
- Translation Initiation · correlation 0.97
- Precursor Cell Cycle · correlation 0.97
- Epithelial Progenitor Differentiation · correlation 0.97
- Metallothionein Stress Response · correlation 0.97
- Mitochondrial Housekeeping · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.