ER Vesicle Trafficking
Gene co-expression module in Tuft cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include SSR2 (ER signal sequence receptor/translocon), TRAPPC1 (TRAPP vesicle tethering complex), ATP6V0E1 (vacuolar H+-ATPase subunit for vesicle acidification), SUMO2 (SUMOylation modifier), and UBE2N (ubiquitin-conjugating enzyme E2N). Together these point to ER-to-Golgi vesicle trafficking and protein quality control. TMEM14C (mitochondrial inner membrane), HSD17B10 (mitochondrial 3-hydroxyacyl-CoA dehydrogenase), and COMMD6 (copper metabolism/ubiquitin pathway) add metabolic and proteostasis components. All genes are enriched in pre_tuft progenitors. In the context of neighbors M35 and M57, this module represents the vesicle trafficking and ubiquitin/SUMO protein modification arm of the pre_tuft biosynthetic program.
Genes
Most correlated modules
- Mitochondrial Housekeeping · correlation 0.97
- Progenitor Cell Proliferation · correlation 0.95
- Mixed OxPhos Secretory · correlation 0.95
- Complex I Antioxidant OxPhos · correlation 0.94
- Proteasome Assembly · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.