mRNA Translation Regulation
Gene co-expression module in Tuft cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes: EIF4A1 and EIF4A3 (eIF4A RNA helicases, translation initiation), PABPC1 (poly-A binding protein, translation/mRNA stability), ZFP36L2 (mRNA decay factor, ZFP36 family), JPT1 (ribosome-associated, translation), TPI1 (glycolytic enzyme, housekeeping but also stress-responsive), SLC20A1 (phosphate transporter, growth/stress), TUBA1B (alpha-tubulin), MCL1 (anti-apoptotic BCL2 family, survival), UGDH (UDP-glucuronate synthesis), FOSL2 (AP-1 TF), MIDN (midnolin, proteasome-related). The dominant theme is mRNA translation initiation and stability (EIF4A1, EIF4A3, PABPC1, JPT1, ZFP36L2), with survival (MCL1) and metabolic support genes. Significantly decreased in UC inflammation and increased post-treatment. Pre_tuft enrichment. This module reflects active translational regulation in pre-tuft progenitors, likely supporting rapid protein synthesis during differentiation or stress recovery. Neighbor context: M29 (stress response) and M83 (heat shock/proteostasis) are co-expressed neighbors; M85 represents the translational arm of the same stress-recovery program.
Genes
Most correlated modules
- Immediate Early Stress · correlation 0.83
- Transcription Elongation Control · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.