Transcription Elongation Control
Gene co-expression module in Tuft cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes include INTS6 (Integrator complex, transcription elongation/pause-release), IER5/IER5L (immediate-early response genes, PP2A regulators), MYCL (MYC family TF), AMD1 (S-adenosylmethionine decarboxylase, polyamine synthesis), MEPCE (7SK snRNA methylphosphatase, P-TEFb regulation), HEXIM1 (P-TEFb inhibitor via 7SK), SRSF7 (splicing factor), PABPC4 (mRNA stability), MAFF/MAFA (bZIP TFs), ATF4 (integrated stress response TF), SOCS1 (JAK-STAT inhibitor), EGR3 (immediate-early TF), NRARP (Notch/WNT regulator). The convergence of HEXIM1, MEPCE, INTS6, and SRSF7 points strongly to transcription elongation control (P-TEFb/7SK axis and Integrator), coupled with immediate-early TF activation. This is a transcriptional pause-release / elongation control program, consistent with rapid gene induction in pre-tuft progenitors. Neighbor context: M29 is an immediate-early stress module also enriched in pre_tuft; M28 likely represents the upstream transcriptional machinery enabling that rapid response.
Genes
Most correlated modules
- mRNA Translation Regulation · correlation 0.77
- Stress Transcriptional Response · correlation 0.64
- Immediate Early Stress · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.