Immediate Early Stress
Gene co-expression module in Tuft cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 15 of 19 genes have a known function matching the annotation |
Why this annotation
The top hub genes are canonical immediate-early response / stress-response transcription factors and phosphatases: DUSP1 (stress-induced MAPK phosphatase), PPP1R15A (GADD34, integrated stress response), ZFP36 (mRNA decay, stress), ATF3 (stress-responsive TF), JUNB, NR4A1, NFKBIZ, ID2, RHOB, PMAIP1 (pro-apoptotic BH3-only), AREG (amphiregulin, stress/repair), ODC1 (polyamine synthesis, stress-growth), PLK3 (stress kinase), ANKRD37 (hypoxia-inducible). The module is enriched in pre_tuft cells and is coherent/core. This is a classic immediate-early gene / integrated stress response program, combining MAPK-pathway immediate-early genes with stress-adaptive transcription factors. The negative correlation with UC inflammation and positive trend with treatment/remission is consistent with a homeostatic stress-response program suppressed during active inflammation. Neighbor context: M28 and M85 also show pre_tuft enrichment and stress/early-response flavors, supporting a shared upstream stress or differentiation signal in pre-tuft cells.
Genes
Most correlated modules
- mRNA Translation Regulation · correlation 0.83
- Stress Transcriptional Response · correlation 0.64
- Heat Shock Response · correlation 0.59
- Transcription Elongation Control · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.