ACKR1 — Atypical chemokine receptor 1 (Duffy blood group)
ACKR1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACKR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venular Inflammatory Activation Inflammation | AIM2, ARL4C, ASAP3, BNC2, CFP, DUSP23, FAM3D, IL18R1 +8 more | View in SCUBA |
About the gene
| Synonyms | CCBP1, CD234, DARC, Dfy, FY, GPD |
|---|---|
| Chromosome | 1: 159203307-159206500 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Blood group antigen proteins, CD markers, G-protein coupled receptors, Predicted membrane proteins, Transporters |
| Molecular function | Blood group antigen, G-protein coupled receptor, Receptor, Transducer |
Function
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels. (Microbial infection) Acts as a receptor for the malaria parasite Plasmodium vivax. (Microbial infection) Acts as a receptor for the malaria parasite Plasmodium knowlesi
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.