IL18R1 — Interleukin 18 receptor 1
IL18R1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL18R1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Inflammatory effector Immune regulation | C3AR1, CAST, CLDND1, CMTM3, CREB3L2, EIF4E3, EPB41, FYCO1 +9 more | View in SCUBA |
| Endothelial | Venular Inflammatory Activation Inflammation | ACKR1, AIM2, ARL4C, ASAP3, BNC2, CFP, DUSP23, FAM3D +8 more | View in SCUBA |
| Mucosal-associated invariant T cell | Tissue Residency Regulation Tissue residence | ABCC1, ANKRD28, ARHGEF7, CA2, CDV3, CHD7, CYTIP, JMY +4 more |
About the gene
| Synonyms | CD218a, IL-1Rrp, IL1RRP |
|---|---|
| Chromosome | 2: 102311529-102398777 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Enzymes, Plasma proteins, Predicted membrane proteins |
| Molecular function | Hydrolase, Receptor |
| Biological process | Inflammatory response |
Function
Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.