Venular Inflammatory Activation
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 17 genes have a known function matching the annotation |
Why this annotation
Top hub genes ACKR1 (atypical chemokine receptor 1, canonical post-capillary venular EC marker) and MADCAM1 (mucosal addressin cell adhesion molecule, gut-specific venular EC) define a gut venular EC inflammatory identity. AIM2 (inflammasome sensor), IL18R1 (IL-18 receptor), CFP (complement properdin), and FAM3D (gut-expressed inflammatory cytokine) reinforce an inflammatory/innate immune signaling program. Strong upregulation in CD inflammation (delta=0.547) and reversal in UC remission supports active inflammatory venular EC activation in IBD.
Genes
ACKR1, AIM2, ARL4C, ASAP3, BNC2, CFP, DUSP23, FAM3D, IL18R1, LHX6, MADCAM1, NPC2, PLEKHA7, PPP2R5A, RAB3C, SCN1B, TPD52L1
Most correlated modules
- Macrophage Contamination · correlation 0.92
- IL33 Alarmin Signaling · correlation 0.90
- Venous EC Identity · correlation 0.89
- Leukocyte Recruitment Signaling · correlation 0.81
- Arterial EC Identity · correlation 0.81
- Angiogenic Metabolic Adaptation · correlation 0.77
- Quiescent EC Identity · correlation 0.77
- Myeloid Contamination · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.