ACO1 — Aconitase 1
ACO1 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACO1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Mitochondrial Peroxisomal Metabolism Mitochondrial & OxPhos | AGPS, ALDH9A1, AP1M2, CAAP1, CCDC47, CDS1, FAM120A, GRSF1 +15 more | View in SCUBA |
About the gene
| Synonyms | IREB1, IREBP, IRP1 |
|---|---|
| Chromosome | 9: 32384603-32454769 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Citric acid cycle related proteins, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Lyase, RNA-binding |
| Biological process | Tricarboxylic acid cycle |
Function
Bifunctional iron sensor that switches between 2 activities depending on iron availability. Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization. Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA. Conversely, when cellular iron levels are high, binds a 4Fe- 4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis- aconitate.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.