Mitochondrial Peroxisomal Metabolism
Gene co-expression module in Colonocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 24 genes have a known function matching the annotation |
Why this annotation
Hub genes include SDHC (Complex II), MTIF2 (mitochondrial translation initiation), IARS2 (mitochondrial isoleucyl-tRNA synthetase), MRPS5 (mitochondrial ribosomal protein), GRSF1 (mitochondrial RNA binding), ACO1 (aconitase/iron-sulfur), HSD17B4 (peroxisomal beta-oxidation), AGPS (peroxisomal ether lipid synthesis), and ALDH9A1 (aldehyde dehydrogenase). The module combines mitochondrial and peroxisomal metabolic functions with uniform expression across colonocyte subsets. PKP2 (desmosomal) and CCDC47 (ER chaperone) are peripheral members. In the context of the neighboring OxPhos modules (M99, M141, M17), this module represents a related but broader mitochondrial/peroxisomal metabolic housekeeping program. Strong coherence with uniform expression supports a constitutive metabolic program.
Genes
Most correlated modules
- Oxidative Phosphorylation · correlation 0.92
- Protein Homeostasis Housekeeping · correlation 0.91
- Colonocyte Differentiation · correlation 0.89
- RNA-binding & Splicing · correlation 0.89
- Mitochondrial Biogenesis · correlation 0.89
- Oxidative Phosphorylation · correlation 0.86
- Mitochondrial Membrane Dynamics · correlation 0.86
- Oxidative Phosphorylation · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.