ACSL6 — Acyl-CoA synthetase long chain family member 6
ACSL6 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACSL6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T cell quiescence Immune regulation | ARL4A, CCDC184, DNAJB9, ETV3, RIMKLB, SERPINB6, SSBP2, TRAPPC2B +3 more | View in SCUBA |
About the gene
| Synonyms | ACS2, FACL6, KIAA0837, LACS2, LACS5 |
|---|---|
| Chromosome | 5: 131949973-132012243 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Ligase |
| Biological process | Fatty acid metabolism, Lipid metabolism |
Function
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl- CoAs produced may be utilized exclusively for the synthesis of the brain lipid.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.