ETV3 — ETS variant transcription factor 3

ETV3 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ETV3's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Plasma cell secretory B cell maturation	AARSD1, ATP1B3, BCAS2, CHMP1B, DNAJB9, ELL2, IDI1, MEPCE +9 more	View in SCUBA
CD4⁺ T cells	T cell quiescence Immune regulation	ACSL6, ARL4A, CCDC184, DNAJB9, RIMKLB, SERPINB6, SSBP2, TRAPPC2B +3 more	View in SCUBA
Gamma-delta T cells	TCR Early Activation TCR Signaling	BTG1, BTG2, CD69, CIRBP, CXCR4, DUSP1, EIF1, FOS +15 more
Innate lymphoid cells	Prostaglandin-AP1 Response Inflammation	ARIH1, ARL5B, CCNT1, CHD1, CXCL2, FOSL2, IRF2BP2, JOSD1 +12 more	View in SCUBA
Macrophages	NF-κB Activation Inflammatory	BCL3, BLOC1S6, CD83, CFLAR, CHMP1B, CNOT2, CSRNP1, CYLD +33 more	View in SCUBA
Monocytes	NR4A Immediate-Early Inflammatory	ANKRD37, CHMP1B, CKS2, CYCS, EIF4A3, GLA, NR4A1, NR4A2 +4 more	View in SCUBA
Mucosal-associated invariant T cell	RNA Processing Stress RNA processing & translation	DDX3X, HSPA5, IVNS1ABP, KDM2A, NAF1, RALGAPA1, SFPQ, SLC2A3 +3 more

About the gene

Synonyms	PE-1
Chromosome	1: 157121191-157138474
Predicted location	Intracellular
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins, Transcription factors
Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Function

Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.