ARL4A — ADP ribosylation factor like GTPase 4A

ARL4A belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ARL4A's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Hypoxia/metabolic stress Stress	ALG13, C9orf72, HIP1R, PDE4B, SC5D, SLC2A3, TENT5C, VPS37B +2 more	View in SCUBA
CD4⁺ T cells	T cell quiescence Immune regulation	ACSL6, CCDC184, DNAJB9, ETV3, RIMKLB, SERPINB6, SSBP2, TRAPPC2B +3 more	View in SCUBA
Endothelial	Inflammatory Stress Response Inflammation	ANKS1A, APH1B, BZW2, C1orf21, CCNG1, CCNG2, DNPH1, EBPL +9 more	View in SCUBA
Gamma-delta T cells	ER Proteotoxic Stress Stress	BCAS2, CCDC59, CSRNP1, CYCS, EIF5, EXOSC6, FOSB, HSPA5 +13 more
Goblet cells	Hypoxia Metabolic Stress Stress	ADGRE5, ANKRD37, FBXO32, IRS2, KLF2, LRRFIP1, SKIL, TENT5A	View in SCUBA
Innate lymphoid cells	NR4A Activation Response activation	ALG13, BCAS2, CASP3, CHMP1B, CREM, DDX24, DLL1, DNAJB9 +16 more	View in SCUBA
Macrophages	Macrophage Lipid Sensing Lipid metabolism	ARL4C, BIRC2, CES2, DDX21, DDX24, DDX27, GPR183, IDI1 +12 more	View in SCUBA
Mucosal-associated invariant T cell	NF-κB Negative Feedback Immune regulation	BCAS2, CSRNP1, CXCR4, ENSG00000285976, IDS, ITPRIP, NFKBIA, NFKBIB +7 more
Pericytes	NF-κB Inflammatory Response Inflammatory	ABL2, ADAMTS9, BCL3, BHLHE40, FOSL2, ICAM1, KLF10, PIM3 +3 more	View in SCUBA

About the gene

Synonyms	ARL4
Chromosome	7: 12686856-12690958
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins

Function

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.