T cell quiescence
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by transcriptional regulators (SSBP2, ETV3, ZSCAN18, ZNF250, ZFP36L2) and stress/ER genes. ZFP36L2 is an mRNA-destabilizing protein important for T cell quiescence; ETV3 is a transcriptional repressor downstream of immune signaling; DNAJB9 is an ER stress/UPR chaperone. The module looks like a quiescence/transcriptional regulation program rather than a defined effector pathway. ZFP36L2 and ETV3 anchor a resting/quiescent T cell state, downregulated in UC inflammation (negative delta). No clear single pathway; best described as a quiescence/transcriptional control module.
Genes
ACSL6, ARL4A, CCDC184, DNAJB9, ETV3, RIMKLB, SERPINB6, SSBP2, TRAPPC2B, ZFP36L2, ZNF250, ZSCAN18
Most correlated modules
- TCR signaling · correlation 0.83
- Resting memory T cell · correlation 0.81
- Unfolded Protein Response · correlation 0.78
- Integrated Stress Response · correlation 0.74
- Naive T cell · correlation 0.73
- T cell signaling · correlation 0.72
- Immediate early activation · correlation 0.67
- Ribosomal proteins · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.