ADGRG4 — Adhesion G protein-coupled receptor G4
ADGRG4 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADGRG4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Secretory progenitor Notch Epithelial development | ADAMTS14, ADCY5, DOCK8, HEPACAM2, MEIS1, NBPF14, NBPF19, NBPF26 +5 more | View in SCUBA |
About the gene
| Synonyms | GPR112, PGR17, RP1-299I16 |
|---|---|
| Chromosome | X: 136300963-136416890 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Plasma proteins, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Orphan adhesion G-protein coupled receptor (aGPCR) (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). ADGRG4 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. May be act as sensor of mechanical forces.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.