MEIS1 — Meis homeobox 1
MEIS1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MEIS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Secretory progenitor Notch Epithelial development | ADAMTS14, ADCY5, ADGRG4, DOCK8, HEPACAM2, NBPF14, NBPF19, NBPF26 +5 more | View in SCUBA |
| Fibroblasts | Neural-crest Fibroblast Developmental | AMIGO2, C1orf54, CENPW, DCLK1, FLRT2, FOXP2, IGFBP4, KIAA0408 +8 more | View in SCUBA |
| Hematopoietic progenitor cells | HSC Quiescence Program Stemness | ADGRG6, AVP, CCDC175, CD164, CDH7, CHRM3, EGLN3, HEMGN +7 more |
About the gene
| Chromosome | 2: 66433452-66573869 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, Developmental protein, DNA-binding |
| Biological process | Transcription |
Function
Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.