ADCY5 — Adenylate cyclase 5
ADCY5 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADCY5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Secretory progenitor Notch Epithelial development | ADAMTS14, ADGRG4, DOCK8, HEPACAM2, MEIS1, NBPF14, NBPF19, NBPF26 +5 more | View in SCUBA |
| Fibroblasts | Smooth Muscle Differentiation Developmental | ASB2, CABP1, CKB, DYSF, FLNC, LIMS2, PGM5, TMEM35A | View in SCUBA |
About the gene
| Synonyms | AC5 |
|---|---|
| Chromosome | 3: 123282296-123449090 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Lyase |
| Biological process | cAMP biosynthesis |
Function
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.