AQP9 — Aquaporin 9
AQP9 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AQP9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Inflammatory Monocyte Activation Inflammatory | ANPEP, CD300E, CD82, CLEC5A, CXXC5, DDX60L, DHRS9, FLNA +25 more | View in SCUBA |
| Monocytes | Inflammatory Monocyte Activation Inflammatory | BACH1, CCR1, DAPP1, DUSP6, FYB1, IFI16, JAK2 | View in SCUBA |
| Neutrophils | Myeloid Inflammatory Activation Inflammatory | CPD, FPR1, ITGAX, LITAF, MXD1, NABP1, NAMPT, SDCBP +5 more |
About the gene
| Synonyms | HsT17287, SSC1 |
|---|---|
| Chromosome | 15: 58138169-58185911 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted membrane proteins, Transporters |
| Biological process | Transport |
Function
Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis (By similarity). It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines. AQP9 may also facilitate hepatic urea extrusion. Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy. Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity. It is also permeable to H2O2 in vivo. Could also be permeable to ammonium (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.