CLEC5A — C-type lectin domain containing 5A
CLEC5A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLEC5A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Inflammatory Monocyte Activation Inflammatory | ANPEP, AQP9, CD300E, CD82, CXXC5, DDX60L, DHRS9, FLNA +25 more | View in SCUBA |
| Monocytes | Monocyte Chemokine Secretion Inflammatory | ACOD1, ADAM19, CCL2, CCL7, CXCL11, GBP3, IL27 | View in SCUBA |
About the gene
| Synonyms | CLECSF5, MDL-1 |
|---|---|
| Chromosome | 7: 141927357-141947007 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Host cell receptor for virus entry, Receptor |
| Biological process | Host-virus interaction, Immunity, Innate immunity |
Function
Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP. Regulates inflammatory responses (By similarity). (Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP. This interaction does not result in viral entry, but stimulates pro-inflammatory cytokine release.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.