CXXC5 — CXXC finger protein 5
CXXC5 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CXXC5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Tfh CXCL13 program B cell help | ASCL2, C11orf96, CD8B2, CXCL13, FILIP1L, FZD3, GFOD1, GNG4 +5 more | View in SCUBA |
| Glial cells | Oxidative Stress Response Stress | CAP1, CD59, EEF2, ENO1, HNRNPF, KLF9, NDUFA11, NFE2L2 +3 more | View in SCUBA |
| Innate lymphoid cells | Actin Cytoskeleton Dynamics Cytoskeleton & motility | ACTN4, ALDH9A1, APBB1IP, ARHGAP10, CDC37, FAM136A, FERMT3, FIP1L1 +26 more | View in SCUBA |
| Macrophages | Inflammatory Monocyte Activation Inflammatory | ANPEP, AQP9, CD300E, CD82, CLEC5A, DDX60L, DHRS9, FLNA +25 more | View in SCUBA |
| Monocytes | MET Tissue Repair Tissue homeostasis | BIN1, EMP2, EVA1C, JRK, MET, MPRIP, NTSR1, RHPN1 +3 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mature Effector MAIT T cell maturation | ADD3, ANTKMT, APOBEC3G, CCL5, FHL3, GZMK, ITGA6, ITGB2 +7 more | |
| Natural Killer cells | Resident NK cells Gut residency | ANXA11, APBB1IP, CD151, HMOX2, LSP1, MPG, PPDPF, SH3BP1 +4 more | View in SCUBA |
About the gene
| Synonyms | HSPC195, RINF, WID |
|---|---|
| Chromosome | 5: 139647299-139683882 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | DNA-binding, Repressor |
| Biological process | Transcription |
Function
May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ. Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.