Inflammatory Monocyte Activation
Gene co-expression module in Macrophages
| Category | Inflammatory |
|---|---|
| Genes | 34 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 34 genes have a known function matching the annotation |
Why this annotation
Hub genes include VCAN (versican, large ECM proteoglycan), SDC2 (syndecan-2, heparan sulfate proteoglycan), ITGA5 (integrin α5, fibronectin receptor), CLEC5A (C-type lectin, DAP12-associated innate immune receptor), TREM1 (triggering receptor on myeloid cells-1, amplifies inflammatory signaling), MCEMP1 (mast cell/monocyte-expressed membrane protein, strong mono_mac marker), SLC11A1 (NRAMP1, iron/metal transporter with antibacterial function), AQP9 (aquaporin-9, water/glycerol channel in monocytes), ANPEP (CD13, aminopeptidase N), MAPK13 (p38δ MAPK, inflammatory signaling), FLNA (filamin A, cytoskeletal/adhesion). TREM1+CLEC5A+SLC11A1+MCEMP1+AQP9 define an inflammatory monocyte-derived macrophage identity. VCAN+SDC2+ITGA5 indicate ECM engagement. This module captures an inflammatory monocyte/macrophage activation state with ECM interaction.
Genes
ANPEP, AQP9, CD300E, CD82, CLEC5A, CXXC5, DDX60L, DHRS9, FLNA, GK5, ITGA5, JAKMIP2, KIFC3, MAPK13, MCEMP1, MGST1, NIBAN2, NRIP3, OLR1, PDLIM7, PLP2, PPARG, RAB13, RAI14, RGCC, S100A8, SDC2, SLAMF9, SLC11A1, SLC25A37, TDP2, TM4SF19, TREM1, VCAN
Most correlated modules
- Monocyte Innate Signaling · correlation 0.89
- Osmotic Stress Response · correlation 0.87
- NF-κB Inflammatory Activation · correlation 0.74
- SPP1 Tissue Remodeling · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.