ANPEP — Alanyl aminopeptidase, membrane
ANPEP belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ANPEP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Chylomicron lipid absorption Lipid metabolism | ACO2, ALDOB, CNDP2, DGAT1, ENPEP, FABP2, MOGAT2, MTTP +3 more | View in SCUBA |
| Fibroblasts | MMP-driven Fibroblast Remodeling ECM remodeling | AKR1B1, COL27A1, COL7A1, CTSL, IL7R, INHBA, MME, MMP1 +4 more | View in SCUBA |
| Macrophages | Inflammatory Monocyte Activation Inflammatory | AQP9, CD300E, CD82, CLEC5A, CXXC5, DDX60L, DHRS9, FLNA +25 more | View in SCUBA |
| Monocytes | Hypoxia Response Tissue adaptation | ELL2, GNA15, HIF1A, NDRG1, RUNX1, SDC4, SLC7A5, SPAG9 +2 more | View in SCUBA |
About the gene
| Synonyms | AP-N, CD13, gp150, hAPN, LAP1, p150, PEPN |
|---|---|
| Chromosome | 15: 89784895-89815401 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins |
| Molecular function | Aminopeptidase, Developmental protein, Host cell receptor for virus entry, Hydrolase, Metalloprotease, Protease, Receptor |
| Biological process | Angiogenesis, Differentiation, Host-virus interaction |
Function
Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity). (Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV- 229E) infection, serves as receptor for HCoV-229E spike glycoprotein. (Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.