ATG13 — Autophagy related 13
ATG13 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATG13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Translation & Proteostasis RNA processing & translation | ARAP2, BRPF1, CLINT1, CRKL, E2F3, EEF2, EIF2AK2, EIF2S3 +15 more |
About the gene
| Synonyms | KIAA0652 |
|---|---|
| Chromosome | 11: 46617527-46674818 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins, Transporters |
| Biological process | Autophagy |
Function
Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.